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KMID : 0357920120460030302
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Korean Journal of Pathology
2012 Volume.46 No. 3 p.302 ~ p.305
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Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report
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Chang Sun-Hee
Joo Mee
Kim Han-Seong
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Abstract
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Carcinoma showing thymus-like differentiation (CASTLE) is a rare carcinoma of the thyroid or adjacent soft tissue of the neck with a histologic resemblance to thymic epithelial tumors. Although the fine-needle aspiration (FNA) plays a central role in the initial evaluation of thyroid nodules, few reports about the cytologic findings of CASTLE have been found according to a review of literatures. We report cytologic findings of a case of CASTLE. A 34-year-old woman presented with a 2-month history of sore throat. The FNA showed that the smear was composed of three dimensional clusters and sheets. The tumor cells were round to ovoid with high nuclear:cytoplasmic ratios. The nuclei were vesicular with small nucleoli. There were some tumor cells showing keratinization. Some lymphocytes were found on the background and within clusters. The presence of poorly-differentiated tumor cells with a focal keratinization and a lymphocytic background on the FNA is suggestive of CASTLE.
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KEYWORD
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Thymoma, Thymus gland, Thyroid gland, Biopsy, fine-needle, Cytodiagnosis
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